TMIO-PyrImid hybrids are profluorescent, site-directed spin labels for nucleic acids.
نویسندگان
چکیده
We report the synthesis of a new class of molecules which are hybrids of long-lived tetramethylisoindolinoxyl (TMIO) radicals and the pyrido[1,2-a]benzimidazole (PyrImid) scaffold. These compounds represent a new lead for noncovalently binding nucleic acid probes, as they interact with nucleic acids with previously unreported C (DNA) and C/U (RNA) complementarity, which can be detected by electron paramagnetic resonance (EPR) techniques. They also have promising properties for fluorimetric analysis, as their fluorescent spin-quenched derivatives exhibit a significant Stokes shift.
منابع مشابه
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عنوان ژورنال:
- Organic letters
دوره 16 21 شماره
صفحات -
تاریخ انتشار 2014